Download A Genetic Switch: Phage Lambda Revisited by Mark Ptashne PDF

By Mark Ptashne

The 1st version of Mark Ptashne's 1986 booklet describing the foundations of gene rules in phage lambda turned a vintage in either content material and shape, environment a typical of readability and special prose that has hardly been bettered. This version is a reprint of the unique textual content, including a brand new bankruptcy updating the tale to 2004. one of the awesome new advancements are contemporary findings on long-range interactions among proteins certain to generally separated websites at the phage genome, and a close description of the way gene activation works.

Show description

Read or Download A Genetic Switch: Phage Lambda Revisited PDF

Best molecular biology books

Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists

A real knowing of genetic and metabolic functionality and layout is facilitated by way of mathematical and computational tools for examining biochemical platforms. This hands-on reference teaches biochemists and molecular biologists using sleek computational equipment for the research of advanced biomedical platforms requiring a modest mathematical history.

Biological Sequence Analysis Using the SeqAn C++ Library (Chapman & Hall CRC Mathematical & Computational Biology)

An Easy-to-Use learn software for set of rules checking out and DevelopmentBefore the SeqAn venture, there has been essentially a scarcity of obtainable implementations in series research, even for normal projects. Implementations of wanted algorithmic parts have been both unavailable or tough to entry in third-party monolithic software program items.

Nutrients and Epigenetics

Explores the Newly stumbled on hyperlink among foodstuff and Epigenetics present learn means that meals are greater than simply meals elements and that sure foodstuff can impression the expression of genes that result in the improvement of continual illnesses. With contributions from specialists in either fields, foodstuff and Epigenetics examines the epigenetic phenomena and the attention-grabbing implications of nutrition in this mostly uncharted box.

The Chemical Bond. Structure and Dynamics

This encouraged e-book by means of essentially the most influential scientists of our time--including six Nobel laureates--chronicles our rising knowing of the chemical bond during the final 9 a long time and into the long run. From Pauling's early paintings at the constitution of the chemical bond utilizing x-ray and electron diffraction to Zewail's paintings at the dynamics of the chemical bond utilizing femtosecond lasers, from Crick's molecular biology to Rich's molecular popularity, this publication explores a wealthy culture of medical background and accomplishment.

Additional info for A Genetic Switch: Phage Lambda Revisited

Sample text

What factors drive the system toward lysis or lysogeny? We do not have a complete understanding of these matters but we can construct a plausible scenario. Briefly put, the decision is effected by a single protein—CII. 10 summarizes the situation. If Cll is highly active the infecting phage lysogenizes; otherwise it grows lytically. Once the decision is made, all other steps of λ growth are determined by one or the other of λ’s developmental programs. 10. The lysis-lysogeny decision. Host proteases regulate the level of activity of CII protein.

19. Repressor is constantly being synthesized as the cells grow and divide, whereas the cro gene remains silent. If the repressor concentration increases—as might happen, for example, were cell division temporarily inhibited—repressor would bind also to OR3 to turn its own gene off. As the cell began dividing again and the repressor concentration dropped to the proper level the cl gene would resume functioning, providing more repressor. Thus a constant level of repressor is maintained in the cell, despite fluctuations in growth rate.

Case 3—Induction In the third case, induction of a lysogen, the phage must make both Int and Xis to ensure its escape from the chromosome following induction. But because we are witnessing the onset of lytic growth we cannot depend on Cll to provide the requisite Int. The solution is as follows: transcription from PL once again produces a mRNA encoding both Int and Xis, but in this case the sib region is not copied onto the end of the mRNA. 13, the process of integration of the phage chromosome separates sib from int and so the mRNA originating at PL bears no sib sequence.

Download PDF sample

Rated 4.95 of 5 – based on 22 votes