By Michael Goodfellow (Eds.)
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Liesch, J. M. and Albers-Schonberg, G. (1985). L-155175: A new antiparasitic macrolide: Fermentation, isolation and structure. Journal of Antibiotics 38, 161-168. 28 R. D. NOLAN A N D T. CROSS Gooday, G. W. and D e Rousset-Hall, A . (1976). Effect of polyoxin D on chitin synthesis in Coprinus cinerea. Transactions of the British Mycological Society 67, 193-200. Goodfellow, M. and Cross, T. (1984). Classification. In: The Biology of the Actinomycetes (M. Goodfellow, M. Mordarski and S. T. Williams, eds), pp.
Journal of Fermentation Technology 47, 463-469. Nonomura, H. and Ohara, Y . (1971a). Distribution of actinomycetes in soil. VIII. Greenspored group of Microtetraspora, its preferential isolation and taxonomic characteristics. Journal of Fermentation Technology 49, 1-7. Nonomura, H. and Ohara, Y. (1971b). Distribution of actinomycetes in soil. IX. N e w species of the genera Microbispora and Microtetraspora and their isolation method. Journal of Fermentation Technology 49, 887-894. Nonomura, H. and Ohara, Y.
A . Directed biosynthesis B. Bioconversion of foreign antibiotics C. Mutasynthesis D . U s e of mutants with blocked or changed biosynthetic pathways E. Cell fusion treatment F. In vivo and in vitro genetic recombination 5. Concluding remarks References 33 35 36 36 38 39 40 41 42 44 48 49 50 50 52 54 55 56 57 58 1. Introduction A c t i n o m y c e t e s h a v e b e e n d e s c r i b e d as t h e g r e a t e s t s o u r c e o f antibiotics s i n c e W a k s m a n i n t r o d u c e d s t r e p t o m y c e t e s i n t o his s y s t e m a t i c s c r e e n i n g p r o g r a m for n e w antibiotics in t h e early 1940s.