Download Advances in Mutagenesis Research by V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter PDF

By V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)

Utilized genetic study, genetic toxicology and mutation study examine the mutagenicity and cancerogenicity of chemical substances and different brokers. everlasting mutation in genes and chromosomes, will be precipitated through aplethora of brokers, together with ionizing and nonionizing radiations, chemical compounds, and viruses. one of the features discused by way of Advances in Mutagenesis study are (1) the certainty of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate creation of mutagenic brokers into the surroundings. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his lifestyles and medical Achievements. - Arylnitrenium Ions and the Genotoxic efficiency of fragrant Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical constitution in a variety of sequence of similar Compounds. - Formation of 8-Hydroxyguanine via Oxidative DNA harm, its fix and its Mutagenic results. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of brought about Mutagenesis by way of Ultraviolet mild in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the identity of SCEs according to mobile Cycle: basics and purposes. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi research. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.

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American Chemical Society, Washington DC, pp 341-370 (ACS Symposium Series 283) Kaiser G, Harnasch D, King M -T, Wild D (1986) Chemical structure and mutagenic activity of aminoimidazoquinolines and aminonaphthimidazoles related to 10 (2-amino-3-methylimidazo [4,5-f]quinoline). Chern Bioi Interact 57:97-106 Kriek E (1965) On the interaction of N-2-ftuorenylhydroxylamine with nucleic acids in vitro. Biochem Biophys Res Commun 20:793-799 Kriek E (1974) Carcinogenesis by aromatic amines. Biochim Biophys Acta 355:177-203 Lai CC, Miller EC, Miller JA, Liem A (1987) Initiation of hepatocarcinogenesis in infant male B6C3F 1 mice by N-hydroxy-2-aminoftuorene or N-hydroxy-2-acetylaminoftuorene depends primarily on metabolism to N-sulfooxy-2-aminoftuorene and formation of DNA(deoxyguanosin-8-yl)-2-aminoftuorene adducts.

31 32 34 40 42 43 1 Introduction In 1982 the analysis of DNA ad ducts was carried out, particularly guanine ad ducts, as one approach to the identification of direct-acting mutagens present in broiled foods and environmental materials. On analysis of adduct formation by heated glucose, as a model of broiled foods, glyoxal-Gua and 8-hydroxy-Gua (oh BGua)l adducts were detected as major products (Kasai, et al. 1984a; Fig. 1). Hydroxylation of Gua at the C-8 position was a new type of guanine modification at that time.

31 32 34 40 42 43 1 Introduction In 1982 the analysis of DNA ad ducts was carried out, particularly guanine ad ducts, as one approach to the identification of direct-acting mutagens present in broiled foods and environmental materials. On analysis of adduct formation by heated glucose, as a model of broiled foods, glyoxal-Gua and 8-hydroxy-Gua (oh BGua)l adducts were detected as major products (Kasai, et al. 1984a; Fig. 1). Hydroxylation of Gua at the C-8 position was a new type of guanine modification at that time.

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