By Michael Wink
Molecular biotechnology maintains to triumph, as this textbook testifies - edited via one of many educational pioneers within the box and written by means of skilled execs. This thoroughly revised moment version covers the full spectrum, from the basics of molecular and phone biology, through an summary of normal tools and applied sciences, the appliance of some of the "-omics", and the improvement of novel drug goals, correct as much as the importance of approach biology in biotechnology. the complete is rounded off by way of an creation to commercial biotechnology in addition to chapters on corporation starting place, patent legislation and advertising.
the hot variation features:
- huge layout and entire colour throughout
- confirmed constitution in response to fundamentals, tools, major issues and financial perspectives
- New sections on procedure biology, RNA interference, microscopic strategies, excessive throughput sequencing, laser purposes, biocatalysis, present biomedical functions and drug approval
- Optimized educating with studying ambitions, a thesaurus containing round 800 entries, over 500 vital abbreviations and extra reading.
the one source when you are heavily drawn to the topic.
Bonus fabric on hand on-line for free: www.wiley-vch.de/home/molecbiotech
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Extra resources for An Introduction to Molecular Biotechnology- Fundamentals, Methods and Applications
If the urea is removed the polypeptide chain refolds into the previous conformation (renaturing). Even though each protein has an individual conformation, when the structures of many proteins are compared, two folding patterns that regularly appear are recognized. These structural elements are: · a-Helix structures. · b-Pleated sheet structures. a-Helix structures and b-pleated sheet structures arise from hydrogen bonds between the N–H and C=O groups in the backbone of the polypeptide chain. Functional groups on the side chains do not take part in these structural elements.
The human body has more than 200 different cell types, which show diverse structures and compositions. These differences must be understood in detail if cell-specific disorders, such as cancer, are to be understood and consequently treated. Before a detailed discussion of cellular structures and their functions (see Chapters 3–5), a short summary of the biochemical basics of cellular and molecular biology is given in Chapter 2. 7 2 Structure and Function of Cellular Macromolecules Learning Objectives This chapter introduces the structure of polysaccharides, lipids, proteins, and nucleic acids, built from simple monomers (sugars, amino acids, and nucleotides), and illustrates how they are derived from simple monomers.
The binding site has a specific spatial structure in which a ligand fits selectively. Binding of the ligand involves the formation of several noncovalent bonds (Fig. 15) between the functional groups of the ligand and those of the protein. Binding generally brings about a change of the protein conformation (induced fit). The binding site is not formed by amino acid residues that lie beside each other on the peptide chain, but often consists of amino acids located in different parts of a peptide chain and spatially form a binding site by appropriate specific folding (Fig.