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By John M. Watson and J. B. Stenlake (Auth.)

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Vivax Gametocytes P. falciparum One nucleus One nucleus Two nuclei Actively amoeboid until halfgrown Occupies all of infected erythrocyte Motility slight. Form ovoid Actively amoeboid throughout Occupies three- Occupies twoquarters of thirds to threeinfected quarters of erythrocyte infected erythrocyte Irregular shape; Normal shape slightly enand size but larged; and with Maurer's with dots (see Schüffner's footnote 3) dots Normal shape but much enlarged; and with Schüffner's dots (see footnote 2) Multiple infect- Multiple infection common tion rare Contains coarse Contains fine granules of granules of dark brown yellow-brown or black pigment pigment Division Dividing forms Dividing forms (schizogony, oval, round or irregular segmentation) band-shaped Merozoites— 6-12 (8-10 usually) Central mass of pigment— symmetrical arrangement Round—fill infected erythrocyte P.

8 Prosthogonimus pellucidus. 11 Euparyphium melis. 9 Cotylophoron cotylophorum. 12 Paramphistomum cervi. —Line beside each drawing indicates actual length of fluke. infected raw or under-cooked fish. Dogs, cats, foxes and other fish-eating mammals are reservoir hosts. This fluke, which closely resembles H. heterophyes in size, form, life-cycle and pathogenesis, is very common in the Far East, and has also been reported from Spain, the Balkan States and Palestine. The snail host is Semisulcospira libertina.

In the latter case the geographical distribution of the intermediate host or hosts limits that of the parasite just as it does in the case of malaria or other insect-transmitted protozoan diseases. ). (2) The eggs hatch on the ground and give rise to free-living juvenile forms which live in the soil and eventually become infective, as in the case of the human hookworms. (3) The eggs hatch after or before leaving the definitive host and give rise to free-living juveniles which establish themselves in an intermediate host, as in the case of the Guinea Worm, Dracunculus medinensis, and the species of the genus Schistosoma.

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