By J. Todd Weber
Fighting, controlling and treating drug-resistant infections is likely one of the significant demanding situations in glossy medication. "Antimicrobial Resistance" is going past uncomplicated definitions and microbiological facts to totally discover this speedily altering zone, describing proof for potent interventions, expenses, therapy recommendations and instructions for destiny examine. each one bankruptcy offers crucial heritage and examines the facts for a tremendous element of prevention and keep watch over, therapy process or coverage choice. Prevention and regulate concepts are analyzed for irrelevant antimicrobial use, fluoroquinolone-resistant organisms, health-care linked infections and parasitic ailments. additionally, therapy ideas for altering resistance styles are explored for community-acquired pneumonia in the course of an influenza pandemic and infections with community-associated MRSA, extended-spectrum beta-lactamase generating organisms and fungi. facts for coverage making are awarded in articles that element the prices of antimicrobial-resistant infections in healthcare settings and the specter of resistance with the advent of antiretroviral remedy for big populations within the constructing international. those reports convey the place interventions, surveillance and study could be most beneficial sooner or later. "Antimicrobial Resistance" is a useful contribution for infectious sickness physicians and public wellbeing and fitness officers who're drawn to the prevention of antimicrobial-resistant infections.
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Extra resources for Antimicrobial Resistance: Beyond the Breakpoint (Issues in Infectious Diseases)
Clin Infect Dis. 2001;32: 1162–1171. 28 Ariffin H, Navaratnam P, Mohamed M, et al: Ceftazidime-resistant Klebsiella pneumoniae bloodstream infection in children with febrile neutropenia. Int J Infect Dis 2000;4:21–25. 29 Mangeney N, Niel P, Paul G, et al: A 5-year epidemiological study of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates in a medium- and long-stay neurological unit. J Appl Microbiol 2000;88:504–511. 30 Bisson G, Fishman NO, Patel JB, Edelstein PH, Lautenbach E: Extended-spectrum beta-lactamaseproducing Escherichia coli and Klebsiella species: risk factors for colonization and impact of antimicrobial formulary interventions on colonization prevalence.
Pneumoniae and E. cloacae, many ESBLproducing E. coli are community acquired [2–9]. Typically, patients with communityacquired ESBL producing E. coli have urinary tract infection, and have infection with the CTX-M type of ESBLs. Some of these urinary tract infections have been associated with bacteremia. Many of these isolates are resistant to commonly used first-line agents for urinary tract infection such as trimethoprim/sulfamethoxazole and ciprofloxacin. Many reports of community-acquired ESBL-producing E.
Expert Opin Investig Drugs 2004;13:1159–1169. 128 LaPlante KL, Rybak MJ: Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model. Antimicrob Agents Chemother 2004;48:4665–4672. 129 Silverman JA, Mortin LI, Vanpraagh AD, Li T, Alder J: Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact. J Infect Dis 2005;191:2149–2152. 130 Fowler VG Jr, Boucher HW, Corey GR, et al: Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus.