By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle
This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in numerous ailment tactics. attainable concepts to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox legislation of mobile responses* scientific implications of redox signaling and antioxidant remedy
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Extra info for Antioxidant and Redox Regulation of Genes
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Using ultraviolet light as a stress agent, they discovered a number of genes that were induced by growth arrest and DNA damage. These so-called "'gadd'" genes were also found to be induced by oxidative stress. , 1992). Since identification of these genes, a growing number of nuclear-encoded mRNAs have also been reported as modulated by reactive oxygen species. , 1998). , 1996). Seven of these are induced and six are reduced. " Interestingly, one of these adapts, adapt15, is expressed coordinately with gadd45 and gadd153 and appears to be a member of the same gadd family.
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