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By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle

This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in numerous ailment tactics. attainable concepts to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox legislation of mobile responses* scientific implications of redox signaling and antioxidant remedy

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Interact. 70, 1-28. , and Hunter, T. (1995). Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus. Curr. Biol. 5, 747-757. Keyse, S. , and Tyrrell, R. M. (1989). Heme oxygenase is the major 32kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. A. 86, 99-103. Klotz, L. , and Sies, H. (1997). Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts.

Using ultraviolet light as a stress agent, they discovered a number of genes that were induced by growth arrest and DNA damage. These so-called "'gadd'" genes were also found to be induced by oxidative stress. , 1992). Since identification of these genes, a growing number of nuclear-encoded mRNAs have also been reported as modulated by reactive oxygen species. , 1998). , 1996). Seven of these are induced and six are reduced. " Interestingly, one of these adapts, adapt15, is expressed coordinately with gadd45 and gadd153 and appears to be a member of the same gadd family.

Adv. Photochem. 6, 1-122. , Johnson, J. , and Krutmann, J. (1996). Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene. Proc. Natl. Acad. Sci. A. 93, 14586-14591. , and Krutmann, J. (1997). Ultraviolet A radiation-induced expression of human genes: Molecular and photobiological mechanisms, Biol. Chem. 378,12311236. Guyton, K. , and Holbrook, N. J. (1996). J. Biol. Chem. 271, 4138-4142. , and Scharffetter-Kochanek, K.

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