Download Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder PDF

By Jacqueline A. Hubbard, Devin K. Binder

Epilepsy is a devastating workforce of neurological issues characterised via periodic and unpredictable seizure task within the brain.  there's a severe want for brand new medications and ways given than a minimum of one-third of all epilepsy sufferers usually are not made freed from seizures by way of latest medicinal drugs and turn into "medically refractory".  a lot of epilepsy examine has concerned with neuronal healing pursuits, yet present antiepileptic medicines frequently reason critical cognitive, developmental, and behavioral uncomfortable side effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity.  additionally, many vital mobile and molecular alterations happen in astrocytes in epileptic tissue in either people and animal versions of epilepsy.  The objective of Astrocytes and Epilepsy is to comprehensively evaluation intriguing findings linking alterations in astrocytes to useful alterations chargeable for epilepsy for the 1st time in publication format.  those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may possibly signify a big new healing goal within the keep an eye on of epilepsy. 

Astrocytes and Epilepsy contains heritage explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue experiences and animal types linking practical adjustments in astrocytes to epilepsy.  superbly labelled diagrams are awarded and correct figures from the literature are reproduced to explain key findings and ideas during this speedily rising field.  Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.

  • Presents the 1st entire publication to synthesize old and up to date learn on astrocytes and epilepsy into one coherent volume
  • Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details power healing objectives, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Show description

Read or Download Astrocytes and Epilepsy PDF

Similar physiology books

Sport and Physical Activity for Mental Health

With nearly 1 in 6 adults more likely to adventure an important psychological illness at anyone time (Office for nationwide Statistics), examine into powerful interventions hasn't ever been extra very important. in past times decade there was an expanding curiosity within the position that game and actual task can play within the remedy of psychological illnesses, and in psychological wellbeing and fitness promoting.

Dynamic Plasma Membranes: Portals Between Cells and Physiology

This quantity focuses on the recent advances in realizing plasma membrane association and serve as starting with easy structures and lengthening to really expert membrane domain names of vertebrate cells. Written by way of major specialists within the fieldContains unique fabric, either textual and illustrative, that are supposed to turn into a really suitable reference materialPresents fabric in a really entire mannerIdeal for either researchers within the box and basic readers who will locate proper and up to date details

Human Biology. Concepts and Current Issues

For classes in human biology   discover Human Biology relating to present concerns, within the textual content and on-line. via his educating, his textbook, and his on-line weblog, award-winning instructor Michael D. Johnson sparks curiosity in human biology by means of connecting uncomplicated biology to real-world concerns which are proper for your existence.

Extra resources for Astrocytes and Epilepsy

Sample text

Similarly, he showed that “perivascular satellites” could also be either oligodendroglia or microglia. ” Interestingly, he may have simultaneously underestimated neuroglia and overestimated neurons in claiming that “oligodendroglia forms by far the most numerous group of cells in the central nervous system, after nerve cells” [91]. In 1924, Wilder Penfield published his work from La Residencia in a seminal article in the journal Brain, “Oligodendroglia and its relation to classical neuroglia” [91].

J Ment Sci 1900;46:724. [90] Achúcarro N. Nuevo método para el estudio de la neuroglia y del tejido conjuntivo. Bol Soc Esp Biol 1911;1:139–41. [91] Penfield W. Oligodendroglia and its relation to classical neuroglia. Brain 1924;47:430–52. [92] Ellison D, Love S. Neuropathology. ; 1998. [93] Sahlas DJ, Bilbao JM, Swartz RH, Black SE. Clasmatodendrosis correlating with periventricular hyperintensity in mixed dementia. Ann Neurol 2002;52(3):378–81. [94] Hulse RE, Winterfield J, Kunkler PE, Kraig RP.

Finally, the emerging concept of neurological diseases as “gliopathies” is considered. Subsequent chapters will more specifically enumerate glial changes in the context of epilepsy, in both human tissue and animal models. 00002-8 39 © 2016 Elsevier Inc. All rights reserved. 40 2. Astrocytes in the Mammalian Brain CLASSIFICATION OF NEUROGLIA AND ASTROCYTE TYPES IN THE CNS Neuroglia are classified into peripheral nervous system (PNS) and central nervous system (CNS) glia (Fig. 1). There are various forms of specialized PNS glia including Schwann cells (responsible for myelinating and surrounding peripheral nerve axons), olfactory ensheathing cells (OECs, found in the olfactory system), satellite glia (found in peripheral ganglia), and enteric glia (in the enteric nervous system).

Download PDF sample

Rated 4.04 of 5 – based on 40 votes