By Jacqueline A. Hubbard, Devin K. Binder
Epilepsy is a devastating workforce of neurological issues characterised via periodic and unpredictable seizure task within the brain. there's a severe want for brand new medications and ways given than a minimum of one-third of all epilepsy sufferers usually are not made freed from seizures by way of latest medicinal drugs and turn into "medically refractory". a lot of epilepsy examine has concerned with neuronal healing pursuits, yet present antiepileptic medicines frequently reason critical cognitive, developmental, and behavioral uncomfortable side effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity. additionally, many vital mobile and molecular alterations happen in astrocytes in epileptic tissue in either people and animal versions of epilepsy. The objective of Astrocytes and Epilepsy is to comprehensively evaluation intriguing findings linking alterations in astrocytes to useful alterations chargeable for epilepsy for the 1st time in publication format. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may possibly signify a big new healing goal within the keep an eye on of epilepsy.
Astrocytes and Epilepsy contains heritage explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue experiences and animal types linking practical adjustments in astrocytes to epilepsy. superbly labelled diagrams are awarded and correct figures from the literature are reproduced to explain key findings and ideas during this speedily rising field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.
- Presents the 1st entire publication to synthesize old and up to date learn on astrocytes and epilepsy into one coherent volume
- Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
- Details power healing objectives, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Extra resources for Astrocytes and Epilepsy
Similarly, he showed that “perivascular satellites” could also be either oligodendroglia or microglia. ” Interestingly, he may have simultaneously underestimated neuroglia and overestimated neurons in claiming that “oligodendroglia forms by far the most numerous group of cells in the central nervous system, after nerve cells” . In 1924, Wilder Penfield published his work from La Residencia in a seminal article in the journal Brain, “Oligodendroglia and its relation to classical neuroglia” .
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Finally, the emerging concept of neurological diseases as “gliopathies” is considered. Subsequent chapters will more specifically enumerate glial changes in the context of epilepsy, in both human tissue and animal models. 00002-8 39 © 2016 Elsevier Inc. All rights reserved. 40 2. Astrocytes in the Mammalian Brain CLASSIFICATION OF NEUROGLIA AND ASTROCYTE TYPES IN THE CNS Neuroglia are classified into peripheral nervous system (PNS) and central nervous system (CNS) glia (Fig. 1). There are various forms of specialized PNS glia including Schwann cells (responsible for myelinating and surrounding peripheral nerve axons), olfactory ensheathing cells (OECs, found in the olfactory system), satellite glia (found in peripheral ganglia), and enteric glia (in the enteric nervous system).