Download Best Practice & Research Clinical Haematology Volume 24, by W. Fibbe PDF

By W. Fibbe

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Extra info for Best Practice & Research Clinical Haematology Volume 24, Issue 1 March 2011

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They are contractile cells, ideally positioned to regulate traffic across the sinusoidal wall in both directions. Their contractile nature is very well in keeping with their nature as a local adaptation of microvascular mural cells/pericytes, otherwise found in all tissues, and long surmised to represent local tissue progenitors [48–51]. Whereas the lineage, nature, and potential diversity of pericytes across tissues remains to be defined (any reference to “pericytes” as a uniform category, or even a uniform cell type [52,53] is simply unwarranted), each and every feature so far indicated as characteristic of a “pericyte” is indeed found in bone marrow osteoprogenitors.

Differentiation 2009;77:483–91. [12] Amado LC, Saliaris AP, Schuleri KH, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A 2005;102:11474–9. [13] Rojas M, Xu J, Woods CR, et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005;33:145–52. [14] Maitra B, Szekely E, Gjini K, et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation.

The experiment [1] consisted in transplanting bone-less fragments of mammalian bone marrow at heterotopic sites. The general biological question being pursued by Tavassoli and Crosby was to determine why hematopoiesis is restricted to bone as the dominant site in post-natal mammals. Within this general context, the specific question tackled by a specific experimental approach (heterotopic transplantation) was whether hematopoiesis can indeed be transplanted to a non-hematopoietic, nonskeletal site.

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