By Leonard Warren
Certain carbohydrates are an enormous and interesting subject in biochemical and melanoma study. in response to a chain of invited lectures, this e-book makes a speciality of the distinctive function that certain carbohydrates play in nature and mirror the author's distinct occupation in biochemical study. another subject matters coated are the homes of membrane glycoproteins, interested in the resistance of cells to medicinal drugs, and the metabolism of sugars and sialic acids, either one of which shape a pivotal position within the author's reviews. The ebook chronicles just a few of the large advances which have been made in biochemistry during the last few a long time.
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Extra resources for Bound Carbohydrates in Nature (Lezioni Lincee)
They illustrate the incredible complexities of the cell and the fine balance necessary to maintain a steady state equilibrium. A defect in the mechanism can result in a serious disease such as sialuria. 30 Derivatives ofneuraminic acid The Af-acetylhexosamine incorporated into sialic acid is derived from D-glucose via the glycolytic pathway intermediate fructose-6phosphate. An outline of the many reactions involving the hexosamines and sialic acids is seen in Scheme 2. All nine carbon atoms of sialic acid are derived from glucose and find their way into neuraminic acid through the intermediates of glycolysis, fructose1-phosphate (C4-9) and phosphoenolpyruvate (Cl-3).
1974) and in Trypanosoma cruzi (Corfield and Schauer, 1982). The erratic distribution of sialic acids among bacteria, and possibly certain protozoa, suggest that the enzymes responsible for their synthesis and metabolism were fortuitously acquired during association with animal cells. Sialic acid-containing bacteria are usually pathogenic (Irani and Ganapathi, 1962; Luppi and Cavazzini, 1966). Cephalopoda Pelecopoda Gastropoda Amphineura Mammalia Aves flnsecta IVERTEBRATAJ Reptilia Arthropods < Crustacea?
There Derivatives of neuraminic acid 44 a6 Glucosidase I (a 1-2 linkage) N _ Castanospermine _ 1-Deoxynojirimycin Glucosidase II (a 1-2 linkage) _ 1-Deoxynojirimycin _ Glucosidase II (a 1-3 linkage) Bromoconduritol 1 -Deoxynojirimycin Mannosidase I (a 1-3 linkage) -AS transferase I Mannosidase II (a 1-3 and a 1-6 linkages) Swainsonine 1 -Deoxynojirimycin- A S N - High mannose oligosaccharide Complex oligosaccharides Hybrid oligosaccharides -ASN- Scheme 9. Early processing of protein-bound carbohydrates.