Download Cardiac Gap Junctions: Physiology, Regulation, by S. Dhein PDF

By S. Dhein

Crucial conversation mechanism among cardiac cells is electric transmission through low resistance pathways, the so-called hole junction channels. This publication presents a entire evaluation of what's recognized approximately cardiac hole junctions. An creation into a number of the features of activation propagation and coupling within the middle is by way of an in depth description of the constitution and variety of hole junctions, together with amino acid sequences and species variability. next chapters speak about their distribution, body structure and services and the legislation of expression. the writer then is going directly to positioned those uncomplicated findings right into a medical context - the adjustments of hole junction distribution during cardiac illness and their implications. an additional bankruptcy offers pharmacological techniques to the modulation of hole junction channel conductivity and descriptions attainable healing recommendations. the ultimate a part of the booklet describes the equipment of research together with double phone voltage clamp, immunohistochemistry, isolation tactics for hole junctions and dye coupling assays.

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Extra info for Cardiac Gap Junctions: Physiology, Regulation, Pathophysiology and Pharmacology

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1993] could not detect Cx43 in the atrioventricular bundle and bundle branches of the rat heart. Similarly, Oosthoek et al. [1993a, b] found expression of Cx43 in the AV bundle and bundle branches in bovine and human hearts but a lack of Cx43 expression in the AV node and the center of the sinoatrial node of human and bovine heart. In the central sinus node of the rat heart these authors did not find Cx43 staining either. In contrast, Anumonwo et al. [1992] reported Cx43 in sinoatrial nodal cell pairs isolated from the rabbit heart, and Trabka-Janik et al.

5 nS) [Bukauskas and Weingart, 1993] so that gj has been assumed to be at least in part enzymatically controlled. Several protein kinases are known to be involved in the regulation of the gap junction channels. However, the situation is rather complicated since the same protein kinase may enhance or reduce gap junctional conductance in different tissues or in different species. Thus, generalizations should be avoided and the specific condition has to be taken into account. , 1986, 1990]. Similarly, an increase in junctional conduc- 35 tance in response to cAMP has been found in cardiac myocytes coupled via Cx43 [Burt and Spray, 1988; De Mello, 1988].

Thus, generalizations should be avoided and the specific condition has to be taken into account. , 1986, 1990]. Similarly, an increase in junctional conduc- 35 tance in response to cAMP has been found in cardiac myocytes coupled via Cx43 [Burt and Spray, 1988; De Mello, 1988]. The changes in conductance are very rapid and occur in several minutes. e. basic-basic-spacer-Ser. , 1990]. This sequence cannot be found in Cx43 so that it has been hypothesized that Cx43 is not subject to direct phosphorylation by PKA.

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