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By Lester Packer

Content material: advent to retinoids / Sheila M. O'Byrne and William S. Blaner -- creation to diet A: a dietary and existence cycle point of view / A. Catharine Ross -- the basic position of diet A in sign transduction / Beatrice Hoyos and Ulrich Hammerling -- Chemical and metabolic oxidation of carotenoids / Frederick Khachik -- hole junctional intercellular communique: carotenoids and retinoids / Wilhelm Stahl and Helmut Sies -- Raman detection of carotenoids in human tissue / Werner Gellermann ... [et al.] -- Macular carotenoids in eye future health / Richard A. Bone and John T. Landrum -- Beta-carotene cleavage items impair mobile and mitochondrial features and should result in genotoxicity / Werner Siems ... [et al.] -- Formation of beta-carotene cleavage items in view of the actual stipulations in infected lung tissue / Olaf Sommerburg ... [et al.] -- organic job of lycopene opposed to smoke-induced lung lesions: concentrating on the IGF-1/IGFBP-3 sign transduction pathway / Xiang-Dong Wang -- Retinoids and carotenoids as melanoma chemopreventive brokers: position of upregulated hole junctional communique / Laura M. Hix ... [et al.] -- Lycopene and hazard of heart problems / Lauren Petr and John W. Erdman, Jr. -- impact of feeding after which depleting a excessive fruit and vegetable vitamin on oxidizability in human serum / Kyung-Jin Yeum ... [et al.] -- Mitochondria as novel ambitions for proapoptotic artificial retinoids / Numsen Hail, Jr., and Reuben Lotan -- Molecuar research of the nutrition A biosynthetic pathway / Johannes von Lintig -- rules of transcription via antioxidant carotenoids / Yoav Sharoni ... [et al.] -- diet A in future health and illness in constructing international locations / Machteld van Lieshout and Clive E. West -- Lycopene and prostate melanoma / Ute C. Obermüller-Jevic and Lester Packer -- Blood reaction to beta-carotene supplementation in people: an evaluate throughout released reports / Klaus Kraemer ... [et al.] -- New horizons in carotenoid examine / Helmut Sies and Wilhelm Stahl -- Carotenoids and heart problems / J. Michael Gaziano and Howard D. Sesso -- security on beta-carotene / Norman I. Krinsky

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20. , and Copyright © 2005 AOCS Press Ch2Carotenoids(23-41)(Co2) 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 6/7/05 9:57 AM Page 39 Chambon, P. (1999) Cellular Retinol-Binding Protein I Is Essential for Vitamin A Homeostasis, EMBO J. 18: 4903–4914. , and Chambon, P. (2002) Analysis of the Visual Cycle in Cellular Retinol-Binding Protein Type I (CRBPI) Knockout Mice, Investig. Ophthalmol. Vis. Sci. 43: 1730–1735. , and Li, E. (2002) Increased Neonatal Mortality in Mice Lacking Cellular Retinol-Binding Protein II, J.

Indeed, a general lesson learned from studies of mice lacking CRBP and/or CRBP II, RBP, or LRAT is that the health of these animals may appear to be normal as long as they are provided with a steady, adequate supply of vitamin A in milk or their postweaning diet (20–23). However, mice lacking genes for CRBP, CRBP II, RBP, or LRAT are markedly compromised in their ability to conserve and adapt to periods of low vitamin A intake. Thus, these binding proteins, and enzymes, appear to function as “efficiency factors,” which provide an important adaptive advantage to species whose access to vitamin A may be infrequent or irregular, whether due to seasonal availability of vitamin A in the food supply, or to other factors that affect nutrient availability.

J. Clin. Nutr. 73: 586–593. 50. , and Harvey, B. (1994) Vitamin A Supplementation and Child Morbidity and Mortality in Developing Countries, Food Nutr. Bull. 15: 282–289. 51. , Jr. (1996) Vitamin A Deficiency: Health, Survival, and Vision, Oxford University Press, New York. 52. B. (1994) Vitamin A Intake and Status Influence Retinol Balance, Utilization and Dynamics in Rats, J. Nutr. 124: 2477–2485. Copyright © 2005 AOCS Press Ch2Carotenoids(23-41)(Co2) 6/7/05 9:57 AM Page 41 53. B. (1996) Quantitative and Conceptual Contributions of Mathematical Modeling to Current Views on Vitamin A Metabolism, Biochemistry, and Nutrition, Adv.

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